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As an injectable cosmetic dermal filler that's FDA-approved for reversing the ravages of age on the skin, Perlane is essentially the same dermal filler as Restylane manufactured by Q-Med but contains larger formulation of hyaluronic acid and larger gel size.

As such, it is more successful in treating moderate to severe cases of facial wrinkles and folds, as well as for lip augmentation and correcting facial depression, whereas Restylane is better at diminishing fine lines and wrinkles. Used to treat severe cases, Perlane can be a more expensive dermal filling treatment than using Restylane.

Origin and Use

Like Restylane, Perlane is a NASHA or non-animal stabilized hyaluronic acid made from fermenting bacteria in the streptococci strain. That means it has no animal-based compounds but behaves just as any other hyaluronic substance extracted from animal tissues. They are also present in humans which makes it bio-compatible as a dermal filler. No allergy test is required prior to having Perlane or Restylane injections.

With age, the hyaluronic acid content gets depleted so that skin gets wrinkled and loses suppleness. Perlane restores the skin's suppleness and resiliency by supplementing the body's natural production of this substance with the right injection to the mid dermal layers of the skin.

As a dermal filler, Perlane's supplementary hyaluronic action benefits the following: wrinkle correction, diminution of worry furrows on the forehead, smile lines of nasolabial lines, crow's feet, marionette lines at mouth corners, smoker lines and is often used for lip augmentation, filling-up cheek depressions due to fat loss, softening scars left by acne and redefining facial lines line chin and jawlines. Minor Perlane uses include filling hallows under the eyebrows, lifting eyebrows and softening eye bags.

Injected Perlane lifts and adds volume to skin that have sagged or thinned as a result of aging. This helps diminished both fine and coarse lines and furrows as well as depressions on the skin

Similar to other dermal filling cosmetic solutions, Perlane treatment results are instant but are temporary, lasting no more than 6 months to a year, depending on the extent of the treatment and the patient's absorption and dissipation of the Perlane substance under their skin .

This is, however, longer than you can expect from collagen injections that last for 3-6 months. Like any non-permanent dermal filling treatment, you will need regular touch-up sessions to replace dissipated Perlane hyaluronic acids under the skin to maintain its effects. The amount of injections is often much less than in the initial session.


Patients with hypersensitivity to hyaluronic substances and have known allergies to drugs requiring hospitalization are best advised to use other dermal fillers. While no allergy tests are required prior to Perlane dermal injections, a consultation with your physician or dermatologist is advised to better gauge your body's readiness to accept hyaluronic injections.

Side effects from Perlane are generally mild and include skin reddening, swelling, itchiness and discoloration in the treated skin areas. These are more often the result of injection reactions than allergic reactions to the Perlane hyaluronic acid and will go away within 1-2 days without medication. Lip enhancement and fat replacement in cheekbones may exhibit longer side effects that often resolve within a week.

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