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It's interesting to read that prior to getting its FDA approval in June of 2006 as a safe cosmetic dermal filler, the hyaluronic acid-based Juvederm was tested at several US medical centers against the then popular Zyplast brand of bovine collagens in treating nasolabial folds or smile folds. One was injected to treat the left smile fold and the other the right smile fold in each of the 146 patients.

After 5 months, the treated subjects were polled on which smile fold looked best and 88% chose the one treated with Juvederm. Since then, this and other clinical tests have favored hyaluronic acids dermal fillers to have the most cost-effective solution to aging skin and have promptly overtaken collagen injections as the more popular non-surgical cosmetic treatment.

How it Works

Juvederm is a cross linked gelatinous compound that works well with cosmetic and plastic surgery. It can absorb 1000 times its own weight in water and thus add volume when injected under the skin. Aging facial skin takes on a more youthful glow because Juvederm's hyaluronic acids bind with the remaining collagen that supports the skin as well as elastin that moves more nutrients to the skin.

It is close to Restylane and Perlane dermal fillers in plumping-up the skin. Recent researches have also revealed that hyaluronic acids in Juvederm stretch the fibroblast skin cells that cause them to create new collagen that are often depleted as we age. At the same time, hyaluronic acids seem to retard the breakdown and depletion of existing collagen. Juvederm is among the many hyaluronic acid based dermal fillers best used by dermatologists and plastic surgeons to soften deep skin folds like nasolabial or smile folds running from the nose sides to the mouth corners, worry furrows, crow's feet, and generally smoothen the skin by diminishing wrinkles.

It is also a dermal fill for lip augmentation, replacing lost fat to pump-up depressed cheeks, as well as elevate depressed scarred skin left by severe acne.

As a non-permanent dermal filler, Juvederm treatment is instant but can last no more than 6-9 months as its hyaluronic acids are eventually dissipated and absorbed by the body. You will need to have regular touch-up sessions with your dermatologist of cosmetologist, usually in 4-6 month intervals, depending on how soon your notices its effects to wear out, if you want to maintain Juvederm's results over a longer period of time. Either that or you can opt to use a more permanent dermal filler like Aquamid or Artefill/ArteColl.

Side Effects

Like any hyaluronic acid-based dermal fillers, Juvederm is bio compatible enough not to require allergy testing prior its treatment. But it is still best to consult with your physician or dermatologist to make sure that you are not one of those with hypersensitivity to hyaluronic acids that require hospitalization to treat.

People with a history of anaphylaxis which is a life-threatening reaction to some drugs and those with allergies to bacteria-based proteins are advised to seek other cosmetic avenues. Otherwise, expect Juvederm to cause some mild side effects like skin reddening, tenderness, swelling and pain in the injected sites which will go away in 1-2 days without treatment. Lip augmentation and cheek fattening treatment may have longer side effects up to a week.

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